10.
Glial cells are crucial for maintaining the stability of the brain, providing support to neurons, and managing oxidative stress. This research examined the cytoprotective effects of the flavonoid Quercetin on C6 glial cells subjected to oxidative stress induced by the chemical hypoxic mimetic Cobalt-Chloride (CoCl2). Treatment with cobalt chloride led to oxidative damage within the cells, indicate...
Shefali Verma and Jyotsna Prasad *
Defence Institute of Physiology and Allied Sciences, D. R. D. O, Delhi, New Delhi, India.
DOI: 10.13040/IJPSR.0975-8232.17(3).881-91
881-891
11.
Objectives: A fixed-dose combination (FDC) of Dapagliflozin, Glimepiride, and Metformin Extended-Release (ER) offers a comprehensive strategy for Type 2 diabetes (T2D), focusing on glycemic control, reduction of cardiovascular (CV) risk, and improved adherence through decreased pill burden. This study aimed to assess the bioequivalence and safety of this FDC in healthy Indian adult volunteers unde...
Kaushik Biswas *, Maddukuri Hanumantha Rao, Bhagyashree Panda, Jay C. Mehta, Sonali Bhojane, Parminder Singh, Thamburaj Anthuvan, Amit Gupta and Smriti Gadia
Department of Endocrinology, Medica Superspeciality Hospital, Kolkata, West Bengal, India.
DOI: 10.13040/IJPSR.0975-8232.17(3).892-00
892-900
12.
The current research was conducted to compare the acute oral toxicity, analgesic and anti-inflammatory properties of ethanolic extracts of Phytanthus fraternus and Impatiens balsamina, two medicinal plants that have been used traditionally in treating pain and inflammation. The acute toxicity was evaluated in Swiss albino mouse based on the OECD guideline 423 at a dose of 300 mg and 2000 mg/kg. Th...
Pratibha S. Gavarkar * and Rajashree S. Chavan
Department of Pharmaceutical Chemistry, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Punrander, Pune, Maharashtra, India.
DOI: 10.13040/IJPSR.0975-8232.17(3).901-07
901-907
13.
Background: Kalanchoe fedtschenkoi is a traditionally used medicinal plant reputed for its antioxidant, antidiabetic, and neuroprotective properties. However, detailed scientific validation of its pharmacognostic and bioactive potential is limited. Objective: This study aimed to evaluate the pharmacognostic characteristics, phytochemical profile, and in-vitro biological activities of K. fedtschenk...
D. Venkateshwari *, Meena Prabha and B. Sangameswaran
Department of Pharmacognosy, SSM College of Pharmacy, Chinniyampalayam, Erode, Tamil Nadu, India.
DOI: 10.13040/IJPSR.0975-8232.17(3).908-20
908-920
14.
Objectives: CYP2C19 is an important enzyme involved in the metabolism of drugs such as proton pump inhibitors, antiplatelets, and antiepileptics. Genetic variations in CYP2C19 can alter drug response and safety. This study aimed to analyze the distribution of three key CYP2C19 variants (*2, *3, *17) and predict metabolizer phenotypes across South Asian, European, and East Asian populations using i...
C. N. Ramya Murthy * and K. G. Satheesh Kumar
Department of Pharmacology, KMC, Kurnool, 104, Shiva Nivas Apartments, Revenue Colony, Kurnool, Andhra Pradesh, India.
DOI: 10.13040/IJPSR.0975-8232.17(3).921-26
921-926